Acetyl chloride → HCID 69290642, compound

HRID 1247427Notes

Reaction equation

[C:1](O)(=[O:3])[CH3:2].[NH2:5][CH2:6][C:7]1[C:8]([F:30])=[C:9]([CH:14]([O:27][CH2:28][CH3:29])[C:15]([NH:17][CH2:18][C:19]2[CH:24]=[CH:23][C:22]([C:25]#[N:26])=[CH:21][CH:20]=2)=[O:16])[C:10]([F:13])=[CH:11][CH:12]=1.C(Cl)(=O)C>>[C:1]([NH:5][CH2:6][C:7]1[C:8]([F:30])=[C:9]([CH:14]([O:27][CH2:28][CH3:29])[C:15]([NH:17][CH2:18][C:19]2[CH:24]=[CH:23][C:22]([C:25]#[N:26])=[CH:21][CH:20]=2)=[O:16])[C:10]([F:13])=[CH:11][CH:12]=1)(=[O:3])[CH3:2]

Participants

Reactant 2

HCID 6367Acetyl chloride

HCID 21905516HCID 21905516, compound

Product 1

HCID 69290642HCID 69290642, compound

Procedure

In analogy to example 87.2 (RS)-2-(3-aminomethyl-2,6-difluoro-phenyl)-N-(4-cyano-benzyl)-2-ethoxy-acetamide acetic acid was reacted with acetyl chloride to give (RS)-2-[3-(acetylamino-methyl)-2,6-difluoro-phenyl]-N-(4-cyano-benzyl)-2-ethoxy-acetamide. White foam. MS 402.5 ([M+H]+)

Sources & evidence

ORD record: ord-807e1e38d39a4e5287b473e762c116e1
Source dataset: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07129238B2

Reaction notes

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