Formic Acid → HCID 69290118, compound

HRID 1247437Notes

Reaction equation

HRID 1247437 reaction equation
C(OC(=O)[NH:7][C:8]([C:10]1[CH:15]=[CH:14][C:13]([CH2:16][NH:17][C:18](=[O:32])[C@H:19]([C:22]2[C:27]([F:28])=[CH:26][C:25]([O:29][CH3:30])=[CH:24][C:23]=2[F:31])[O:20][CH3:21])=[CH:12][CH:11]=1)=[NH:9])(C)(C)C.C(O)=O>O>[C:8]([C:10]1[CH:11]=[CH:12][C:13]([CH2:16][NH:17][C:18](=[O:32])[C@H:19]([C:22]2[C:27]([F:28])=[CH:26][C:25]([O:29][CH3:30])=[CH:24][C:23]=2[F:31])[O:20][CH3:21])=[CH:14][CH:15]=1)(=[NH:7])[NH2:9]

Participants

4

Reactant 2

HCID 284Formic AcidHCID 140474517HCID 140474517, compound

Product 1

HCID 69290118HCID 69290118, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A suspension of (S)-[(4-{[2-(2,6-difluoro-4-methoxy-phenyl)-2-methoxy-acetylamino]-methyl}-phenyl)-imino-methyl]-carbamic acid tert-butyl ester in water was treated with formic acid. The solution was stirred for 8 hrs at rt, then concentrated, redissolved twice in water, concentrated and dried to give (S)-N-(4-carbamimidoyl-benzyl)-2-(2,6-difluoro-4-methoxy-phenyl)-2-methoxy-acetamide formiate (78 mg) as white foam. MS 364.1 ([M+H]+)

Workup

  1. concentrationconcentrated
  2. dissolutionredissolved twice in water
  3. concentrationconcentrated
  4. customdried

Sources & evidence

ORD record
ord-0d45826d9bf643f68491f9df83797e19
Source dataset
uspto-grants-2006_10
Patent number
US07129238B2

Reaction notes

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