HCID 69516493, compound → HCID 86595446, compound

HRID 1247552Notes

Reaction equation

HRID 1247552 reaction equation
[CH2:1]([O:3][C:4](=[O:25])[C:5]([OH:24])([C:20]([F:23])([F:22])[F:21])[CH2:6][C:7]([C:10]1[CH:15]=[C:14]([F:16])[CH:13]=[CH:12][C:11]=1[N+:17]([O-:19])=[O:18])([CH3:9])[CH3:8])[CH3:2].[CH2:26]([O:28][C:29](=[O:50])[C:30]([OH:49])([C:45]([F:48])([F:47])[F:46])[CH2:31][C:32]([C:35]1[CH:40]=[CH:39][C:38]([N+:41]([O-:43])=[O:42])=[C:37]([F:44])[CH:36]=1)([CH3:34])[CH3:33])[CH3:27]>CCCCCC.C(OCC)(=O)C>[CH2:26]([O:28][C:29](=[O:50])[C:30]([OH:49])([C:45]([F:48])([F:47])[F:46])[CH2:31][C:32]([C:35]1[CH:40]=[CH:39][C:38]([N+:41]([O-:43])=[O:42])=[C:37]([F:44])[CH:36]=1)([CH3:34])[CH3:33])[CH3:27].[CH2:1]([O:3][C:4](=[O:25])[C:5]([OH:24])([C:20]([F:21])([F:22])[F:23])[CH2:6][C:7]([C:10]1[CH:15]=[C:14]([F:16])[CH:13]=[CH:12][C:11]=1[N+:17]([O-:19])=[O:18])([CH3:9])[CH3:8])[CH3:2]

Participants

4

Reactant 2

HCID 69516493HCID 69516493, compoundHCID 69516804HCID 69516804, compound

Product 1

HCID 86595446HCID 86595446, compound

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

From the mother liquor, after chromatography on silica gel with hexane-ethyl acetate (8:1), another 500 mg of 4-(5-fluoro-2-nitrophenyl)-2-hydroxy-4-methyl-2-trifluoromethylvaleric acid-ethyl ester accumulates as a first fraction, and 800 mg of 4-(3-fluoro-4-nitrophenyl)-2-hydroxy-4-methyl-2-trifluoromethylvaleric acid-ethyl ester as an oil accumulates as a second fraction.

Sources & evidence

ORD record
ord-1b826c26ad3f400d891ffe1f0b72edae
Source dataset
uspto-grants-2006_10
Patent number
US07129270B2

Reaction notes

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