1,4-Dioxane → HCID 21906726, compound

HRID 1247603Notes

Reaction equation

HRID 1247603 reaction equation
[C:1]12([CH2:11][NH:12][C:13]([C:15]3[C:20]([Cl:21])=[CH:19][N:18]=[C:17]([N:22](CCO)[CH2:23][CH2:24][NH:25][C:26](=O)OC(C)(C)C)[CH:16]=3)=[O:14])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[O:36]1CCOC[CH2:37]1>Cl>[ClH:21].[ClH:21].[C:1]12([CH2:11][NH:12][C:13](=[O:14])[C:15]3[C:20]([Cl:21])=[CH:19][N:18]=[C:17]([NH:22][CH2:23][CH2:24][NH:25][CH2:26][CH2:37][OH:36])[CH:16]=3)[CH2:2][CH:3]3[CH2:9][CH:7]([CH2:6][CH:5]([CH2:4]3)[CH2:10]1)[CH2:8]2

Participants

4

Reactant 2

HCID 312751,4-DioxaneHCID 21906691HCID 21906691, compound

Product 1

HCID 21906726HCID 21906726, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

tert-Butyl 2-[(4-{[(1-adamantylmethyl)amino]carbonyl}-5-chloropyridin-2-yl)(2-hydroxyethyl)amino]ethylcarbamate (Example 13(i)) (0.013 g) was dissolved in anhydrous hydrogen chloride in 1,4-dioxane (4M, 2 ml) and the resulting mixture was allowed to stand at room temperature for 30 minutes. The mixture was concentrated under reduced pressure to afford the titled product (0.020 g).

Workup

  1. concentrationThe mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-42cfaaa5e520486aa3cad6983a279775
Source dataset
uspto-grants-2006_10
Patent number
US07129246B2

Reaction notes

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