反应详情

温度

60 °C

Sodium iodide (0.48 g) was added to a solution of trimethylsilylchloride (0.41 ml) in acetonitrile (30 ml) and the mixture was stirred for 1 hour. N-(1-Adamantylmethyl)-5-bromo-2-methoxyisonicotinamide (0.94 g) (Example 35(i)) was then added and the reaction mixture was heated at 60° C. under nitrogen for 3 hours. The reaction mixture was diluted with water (150 ml) and the resultant solid was collected by filtration and dried by means of ethanol/toluene azeotrope. The solid was triturated with diethyl ether and collected by filtration to afford the sub-titled compound (0.70 g).

1. filtrationthe resultant solid was collected by filtration
2. dry with materialdried by means of ethanol/toluene azeotrope
3. customThe solid was triturated with diethyl ether
4. filtrationcollected by filtration