反应详情

温度

0 °C

1.5 g 4-Methylamino-2-methylsulfanyl-pyrimidine-5-carbaldehyde (prepared according to WO 00/24744) were dissolved in 30 mL THF. 14 mL of a 1.4 M solution of methyl magnesium bromide in ether were added drop-wise below 5° C. After stirring for 1 hr at 0° C., another 14 mL Grignard solution were added within 30 min. Stirring was continued for 30 min at 0° C. and finally at RT for 25 hrs. The mixture was quenched with saturated ammonium chloride solution and extracted with ethyl acetate.

1. additionanother 14 mL Grignard solution were added within 30 min
2. stirringStirring
3. waitwas continued for 30 min at 0° C. and finally at RT for 25 hrs
4. customThe mixture was quenched with saturated ammonium chloride solution
5. extractionextracted with ethyl acetate