Sodium Hydroxide → HCID 10326816, compound

HRID 1247665Notes

Reaction equation

HRID 1247665 reaction equation
C[O:2][C:3](=[O:31])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([S:12][CH2:13][CH:14]=[C:15]([C:23]2[CH:28]=[CH:27][C:26]([I:29])=[CH:25][CH:24]=2)[C:16]2[CH:21]=[CH:20][C:19]([I:22])=[CH:18][CH:17]=2)=[CH:8][C:7]=1[CH3:30].[OH-].[Na+]>C(O)C>[I:29][C:26]1[CH:25]=[CH:24][C:23]([C:15]([C:16]2[CH:21]=[CH:20][C:19]([I:22])=[CH:18][CH:17]=2)=[CH:14][CH2:13][S:12][C:9]2[CH:10]=[CH:11][C:6]([O:5][CH2:4][C:3]([OH:31])=[O:2])=[C:7]([CH3:30])[CH:8]=2)=[CH:28][CH:27]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 10009527HCID 10009527, compound

Product 1

HCID 10326816HCID 10326816, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

{4-[3,3-Bis-(4-iodo-phenyl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid methyl ester (342 mg, 0.5 mmol) was dissolved in warm ethanol (20 ml). 1N NaOH was added at room temperature and the reaction mixture was stirred for 1 h after which it was evaporated. The residue was treated with 1N HCl (1.0 ml) and extracted with dichloromethane (3×20 ml). The combined organic phases were dried and evapotated to give the title compound in 320 mg (96%) yield.

Workup

  1. customwas evaporated
  2. additionThe residue was treated with 1N HCl (1.0 ml)
  3. extractionextracted with dichloromethane (3×20 ml)
  4. customThe combined organic phases were dried

Sources & evidence

ORD record
ord-094b6232b7c7426b88bb4fef88cb72c8
Source dataset
uspto-grants-2006_10
Patent number
US07129268B2

Reaction notes

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