Sodium Hydroxide → HCID 10326816, compound

Participants

Reaction Steps

{4-[3,3-Bis-(4-iodo-phenyl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid methyl ester (342 mg, 0.5 mmol) was dissolved in warm ethanol (20 ml). 1N NaOH was added at room temperature and the reaction mixture was stirred for 1 h after which it was evaporated. The residue was treated with 1N HCl (1.0 ml) and extracted with dichloromethane (3×20 ml). The combined organic phases were dried and evapotated to give the title compound in 320 mg (96%) yield.

Provenance & Evidence