Sodium Hydroxide → HCID 11756838, compound

HRID 1247667Notes

Reaction equation

HRID 1247667 reaction equation
C[O:2][C:3](=[O:31])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][CH:14]=[C:15]([C:23]2[CH:28]=[CH:27][C:26]([Br:29])=[CH:25][CH:24]=2)[C:16]2[CH:21]=[CH:20][C:19]([Br:22])=[CH:18][CH:17]=2)=[CH:8][C:7]=1[CH3:30].[OH-].[Na+]>C(O)C>[Br:22][C:19]1[CH:18]=[CH:17][C:16]([C:15]([C:23]2[CH:28]=[CH:27][C:26]([Br:29])=[CH:25][CH:24]=2)=[CH:14][CH2:13][O:12][C:9]2[CH:10]=[CH:11][C:6]([O:5][CH2:4][C:3]([OH:31])=[O:2])=[C:7]([CH3:30])[CH:8]=2)=[CH:21][CH:20]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 10053169HCID 10053169, compound

Product 1

HCID 11756838HCID 11756838, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
60 °C

Procedure

{4-[3,3-Bis-(4-bromo-phenyl)-allyloxy]-2-methyl-phenoxy}-acetic acid methyl ester (1.9 g, 3.5 mmol) was dissolved in warm ethanol (100 ml). 1N NaOH (7 ml, 7 mmol) was added and the reaction mixture was stirred for 2 h at 60° C. after which it was evaporated. The residue was treated with water (50 ml) and 1N HCl (8 ml) and extracted with dichloromethane (2×250 ml). The combined organic phases were dried and evaporated to give the title compound in 1.8 g (99%) yield.

Workup

  1. customwas evaporated
  2. additionThe residue was treated with water (50 ml) and 1N HCl (8 ml)
  3. extractionextracted with dichloromethane (2×250 ml)
  4. customThe combined organic phases were dried
  5. customevaporated

Sources & evidence

ORD record
ord-f0ea411f7cf94d25b7e1cd50a64e3dbb
Source dataset
uspto-grants-2006_10
Patent number
US07129268B2

Reaction notes

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