Hydrochloric Acid → HCID 10324587, compound

HRID 1247669Notes

Reaction equation

HRID 1247669 reaction equation
C[O:2][C:3](=[O:37])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([S:12][CH2:13][CH:14]=[C:15]([C:26]2[CH:31]=[CH:30][CH:29]=[C:28]([C:32]([F:35])([F:34])[F:33])[CH:27]=2)[C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([F:25])([F:24])[F:23])[CH:17]=2)=[CH:8][C:7]=1[CH3:36].C(O)C.Cl>>[F:34][C:32]([F:33])([F:35])[C:28]1[CH:27]=[C:26]([C:15]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([F:24])([F:25])[F:23])[CH:17]=2)=[CH:14][CH2:13][S:12][C:9]2[CH:10]=[CH:11][C:6]([O:5][CH2:4][C:3]([OH:37])=[O:2])=[C:7]([CH3:36])[CH:8]=2)[CH:31]=[CH:30][CH:29]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 10437294HCID 10437294, compound

Product 1

HCID 10324587HCID 10324587, compound

Conditions

Temperature
5 °C

Procedure

{4-[3,3-Bis-(3-trifluoromethyl-phenyl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid methyl ester (100 mg, 0.23 mmol) was dissolved in ethanol (10 ml).1N NaOH (3 ml, 3 mmol) was added at room temperature and the reaction mixture was stirred for 18 h at 5° C. after which it was treated with 1N HCl (3 ml) and extracted with dichloromethane (2×20 ml). The combined organic phases were dried and evapotated to give the title compound in 20 mg (5%) yield.

Workup

  1. additionwas added at room temperature
  2. extractionextracted with dichloromethane (2×20 ml)
  3. customThe combined organic phases were dried

Sources & evidence

ORD record
ord-0e141c83e62a4f31a530e71b880fc462
Source dataset
uspto-grants-2006_10
Patent number
US07129268B2

Reaction notes

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