HCID 68575962, compound → HCID 9980047, compound

HRID 1247681Notes

Reaction equation

HRID 1247681 reaction equation
C([O:3][C:4](=[O:31])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH:15]=[C:16]([C:24]2[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][CH:25]=2)[C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)=[CH:9][CH:8]=1)C>[OH-].[Na+].C(O)C>[Cl:23][C:20]1[CH:19]=[CH:18][C:17]([C:16]([C:24]2[CH:25]=[CH:26][C:27]([Cl:30])=[CH:28][CH:29]=2)=[CH:15][CH2:14][O:13][C:10]2[CH:11]=[CH:12][C:7]([O:6][CH2:5][C:4]([OH:31])=[O:3])=[CH:8][CH:9]=2)=[CH:22][CH:21]=1

Participants

4

Reactant 1

HCID 68575962HCID 68575962, compound

Product 1

HCID 9980047HCID 9980047, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

A solution of {4-[3,3-bis-(4-chloro-phenyl)-allyloxy]-phenoxy}-acetic acid ethyl ester (140 mg, 0.3 mmol) in 1N NaOH (1 ml) and ethanol (10 ml) was stirred at room temperature for 18 hours. The reaxtion mixture was evaporated and the residue dissolved in water (5 ml) and 1 N HCl (1.2 ml). The aquous phase was extracted with ethyl acetate (3×15 ml), dried (MgSO4) and evaporated to give the title compound in 130 mg (99%) yield.

Workup

  1. customThe reaxtion mixture was evaporated
  2. dissolutionthe residue dissolved in water (5 ml)
  3. extractionThe aquous phase was extracted with ethyl acetate (3×15 ml)
  4. dry with materialdried (MgSO4)
  5. customevaporated

Sources & evidence

ORD record
ord-658fe31175c14eeab5bad6db4c756a73
Source dataset
uspto-grants-2006_10
Patent number
US07129268B2

Reaction notes

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