Hydrochloric Acid → HCID 10461999, compound

Participants

Reaction Steps

{4-[3,3-Bis-(4-iodo-phenyl)-allylsulfanyl]-2-methoxy-phenoxy}-acetic acid methyl ester (290 mg, 0.43 mmol) was dissolved in warm ethanol (30 ml). 1N NaOH (2 ml) was added at room temperature and the reaction mixture was stirred for 2 h after which it was evapo-rated. The residue was treated with 1N HCl (2.4 ml) and extracted with dichloromethane (3×25 ml). The combined organic phases were dried and evaporated to give the title compound in 275 mg (97%) yield.

Provenance & Evidence