Hydrochloric Acid → HCID 10461999, compound

HRID 1247690Notes

Reaction equation

HRID 1247690 reaction equation
C[O:2][C:3](=[O:32])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([S:12][CH2:13][CH:14]=[C:15]([C:23]2[CH:28]=[CH:27][C:26]([I:29])=[CH:25][CH:24]=2)[C:16]2[CH:21]=[CH:20][C:19]([I:22])=[CH:18][CH:17]=2)=[CH:8][C:7]=1[O:30][CH3:31].[OH-].[Na+].Cl>C(O)C>[I:22][C:19]1[CH:18]=[CH:17][C:16]([C:15]([C:23]2[CH:28]=[CH:27][C:26]([I:29])=[CH:25][CH:24]=2)=[CH:14][CH2:13][S:12][C:9]2[CH:10]=[CH:11][C:6]([O:5][CH2:4][C:3]([OH:32])=[O:2])=[C:7]([O:30][CH3:31])[CH:8]=2)=[CH:21][CH:20]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 68575822HCID 68575822, compound

Product 1

HCID 10461999HCID 10461999, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

{4-[3,3-Bis-(4-iodo-phenyl)-allylsulfanyl]-2-methoxy-phenoxy}-acetic acid methyl ester (290 mg, 0.43 mmol) was dissolved in warm ethanol (30 ml). 1N NaOH (2 ml) was added at room temperature and the reaction mixture was stirred for 2 h after which it was evapo-rated. The residue was treated with 1N HCl (2.4 ml) and extracted with dichloromethane (3×25 ml). The combined organic phases were dried and evaporated to give the title compound in 275 mg (97%) yield.

Workup

  1. extractionextracted with dichloromethane (3×25 ml)
  2. customThe combined organic phases were dried
  3. customevaporated

Sources & evidence

ORD record
ord-8e69b14d8fac41c19554c4aaae63146e
Source dataset
uspto-grants-2006_10
Patent number
US07129268B2

Reaction notes

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