Hydrochloric Acid → HCID 10073633, compound

HRID 1247691Notes

Reaction equation

HRID 1247691 reaction equation
C[O:2][C:3](=[O:32])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([S:12][CH2:13][CH:14]=[C:15]([C:23]2[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=2)[C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)=[CH:8][C:7]=1[O:30][CH3:31].[OH-].[Na+].Cl>C(O)C>[Cl:22][C:19]1[CH:18]=[CH:17][C:16]([C:15]([C:23]2[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=2)=[CH:14][CH2:13][S:12][C:9]2[CH:10]=[CH:11][C:6]([O:5][CH2:4][C:3]([OH:32])=[O:2])=[C:7]([O:30][CH3:31])[CH:8]=2)=[CH:21][CH:20]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 68575776HCID 68575776, compound

Product 1

HCID 10073633HCID 10073633, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

{4-[3,3-Bis-(4-chlorophenyl)-allylsulfanyl]-2-methoxy-phenoxy}-acetic acid methyl ester (280 mg, 0.57 mmol) was dissolved in warm ethanol (10 ml). 1N NaOH (1 ml) was added at room temperature and the reaction mixture was stirred for 2 h after which it was evapo-rated. The residue was treated with 1N HCl (1.2 ml) and extracted with dichloromethane (3×25 ml). The combined organic phases were dried and evaporated to give the title compound in 245 mg (90%) yield.

Workup

  1. extractionextracted with dichloromethane (3×25 ml)
  2. customThe combined organic phases were dried
  3. customevaporated

Sources & evidence

ORD record
ord-31a1dafd2f3d4908992378168b6b818d
Source dataset
uspto-grants-2006_10
Patent number
US07129268B2

Reaction notes

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