Methanol → HCID 86596485, compound

HRID 1247697Notes

Reaction equation

[CH3:1][OH:2].CC1C=CC([S:10]([OH:13])(=[O:12])=[O:11])=CC=1.[CH:14]([Cl:17])([Cl:16])[Cl:15]>>[CH:14]([Cl:17])([Cl:16])[Cl:15].[CH3:1][OH:2].[S:10](=[O:11])(=[O:2])([OH:12])[OH:13]

Participants

Reactant 3

HCID 887Methanol

HCID 6101p-Toluenesulfonic acid

HCID 6212Chloroform

Product 1

HCID 86596485HCID 86596485, compound

Procedure

A colorless solid (yield: 90.9%) was obtained through reaction conducted as in example 54 except that the reactants were replaced by the compound (123) prepared in example 23 (0.5 g), methanol (42.7 mL), chloroform (42.7 mL) and p-toluene sulfonate (4.43 g), the reaction temperature was lowered to room temperature and the reaction time was extended to 72 hours. 1H-NMR data showed that the product consisted of a compound (144) and the compound (123) (content of compound (144): 89.0 mol %).

Workup

customwas lowered to room temperature

Sources & evidence

ORD record: ord-26e58180a3dc45ea855410ae75652e2f
Source dataset: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07129370B2

Reaction notes

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