Hydrochloric Acid → 5-Amino-1-methyl-4-nitrosopyrazole
Reaction equation
[NH2:1][C:2]1[N:6]([CH3:7])[N:5]=[CH:4][CH:3]=1.Cl.[N:9]([O-])=[O:10].[Na+]>O>[NH2:1][C:2]1[N:6]([CH3:7])[N:5]=[CH:4][C:3]=1[N:9]=[O:10]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 5 °C
Procedure
To a solution of 5-amino-1-methylpyrazole (100 g) in water (700 ml) were added concentrated hydrochloric acid (86 ml) and sodium nitrite (63.9 g) in water (200 ml) at a temperature below 10° C. The reaction mixture was stirred at 5° C. for 30 minutes. The precipitated solid was collected by filtration and dried to give 5-amino-1-methyl-4-nitrosopyrazole (117 g).
Workup
- filtrationThe precipitated solid was collected by filtration
- customdried
Sources & evidence
- ORD record
- ord-cbbefbb5ddb94df9bd2938c0f4350047
- Source dataset
- uspto-grants-2006_10
- Patent number
- US07129232B2
Reaction notes
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