反应详情

2-(2-Guanidino-4-thiazolylmethylthio)ethylamine is heated under reflux in pyridine for 12 hours with 0.75 molar equivalents of 2-nitroamino-5-(4-methoxy-2-pyridylmethyl)-4-pyrimidone to give 2-[2-(2-guanidino-4-thiazolylmethylthio)ethylamino]-5-(4-methoxy-2-pyridylmethyl)-4-pyrimidone. When this product is boiled under reflux in 2N hydrogen bromide in ethanol 2-[2-(2-guanidino-4-thiazolylmethylthio)ethylamino]-5-(4-hydroxy-2-pyridylmethyl)-4-pyrimidone trihydrobromide is produced.