HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Nitroamino-5-(4-methoxy-2-pyridylmethyl)-4-pyrimidone → HCID 178493129, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Nitroamino-5-(4-methoxy-2-pyridylmethyl)-4-pyrimidone | HCID 12783834 | — |
| Reactant | 2-[4-(2-Aminoethylsulfanylmethyl)-1,3-thiazol-2-yl]guanidine | HCID 178512723 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 178493129 | HCID 178493129 | — |
Reaction Steps
2-(2-Guanidino-4-thiazolylmethylthio)ethylamine is heated under reflux in pyridine for 12 hours with 0.75 molar equivalents of 2-nitroamino-5-(4-methoxy-2-pyridylmethyl)-4-pyrimidone to give 2-[2-(2-guanidino-4-thiazolylmethylthio)ethylamino]-5-(4-methoxy-2-pyridylmethyl)-4-pyrimidone. When this product is boiled under reflux in 2N hydrogen bromide in ethanol 2-[2-(2-guanidino-4-thiazolylmethylthio)ethylamino]-5-(4-hydroxy-2-pyridylmethyl)-4-pyrimidone trihydrobromide is produced.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04521418 |
| Source dataset | uspto-grants-1985_06 |
| ORD ID | ord-b8e703823e5c471fa5132def46a1d99f |
| Source note | uspto-grants-1985_06 |