5-(5,6-Dimethyl-3-pyridylmethyl)-2-nitroamino4-pyrimidone → HCID 178423876, compound

HRID 1247902Notes

Reaction equation

HRID 1247902 reaction equation
[NH:1]([C:5]1[S:6][CH:7]=[C:8]([CH2:10][S:11][CH2:12][CH2:13][NH2:14])[N:9]=1)[C:2]([NH2:4])=[NH:3].[N+](N[C:19]1[NH:24][C:23](=[O:25])[C:22]([CH2:26][C:27]2[CH:28]=[N:29][C:30]([CH3:34])=[C:31]([CH3:33])[CH:32]=2)=[CH:21][N:20]=1)([O-])=O>N1C=CC=CC=1>[NH:1]([C:5]1[S:6][CH:7]=[C:8]([CH2:10][S:11][CH2:12][CH2:13][NH:14][C:19]2[NH:24][C:23](=[O:25])[C:22]([CH2:26][C:27]3[CH:28]=[N:29][C:30]([CH3:34])=[C:31]([CH3:33])[CH:32]=3)=[CH:21][N:20]=2)[N:9]=1)[C:2]([NH2:4])=[NH:3]

Participants

4

Reactant 2

HCID 127838315-(5,6-Dimethyl-3-pyridylmethyl)-2-nitroamino4-pyrimidoneHCID 1785127232-[4-(2-Aminoethylsulfanylmethyl)-1,3-thiazol-2-yl]guanidine

Product 1

HCID 178423876HCID 178423876, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

2-(2-Guanidino-4-thiazolylmethylthio)ethylamine is heated under reflux in pyridine for 12 hours with 1.5 molar equivalents of 2-nitroamino-5-(5,6-dimethyl-3-pyridylmethyl)-4-pyrimidone to give 2-[2-(2-guanidino-4-thiazolylmethylthio)ethylamino]-5-(5,6-dimethyl-3-pyridylmethyl)-4-pyrimidone.

Sources & evidence

ORD record
ord-ae06d64f3d48455b98cb95fc4c051d2d
Source dataset
uspto-grants-1985_06
Patent number
US04521418

Reaction notes

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