Sodium ethoxide → HCID 178424600, compound

HRID 1247903Notes

Reaction equation

HRID 1247903 reaction equation
Cl.[NH:2]([C:6]1[S:7][CH:8]=[C:9]([CH2:11]Cl)[N:10]=1)[C:3]([NH2:5])=[NH:4].[SH:13][CH2:14][CH2:15][NH:16][C:17]1[NH:22][C:21](=[O:23])[C:20]([CH2:24][C:25]2[CH:26]=[N:27][C:28]([CH3:31])=[CH:29][CH:30]=2)=[CH:19][N:18]=1.[O-]CC.[Na+]>C(O)C>[NH:2]([C:6]1[S:7][CH:8]=[C:9]([CH2:11][S:13][CH2:14][CH2:15][NH:16][C:17]2[NH:22][C:21](=[O:23])[C:20]([CH2:24][C:25]3[CH:26]=[N:27][C:28]([CH3:31])=[CH:29][CH:30]=3)=[CH:19][N:18]=2)[N:10]=1)[C:3]([NH2:5])=[NH:4]

Participants

5

Reactant 3

HCID 2723922Sodium ethoxideHCID 135372312-(2-Mercaptoethylamino)-5-(6-methyl-3-pyridylmethyl)-4-pyrimidoneHCID 178479412HCID 178479412, compound

Product 1

HCID 178424600HCID 178424600, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-Guanidino-4-chloromethylthiazole hydrochloride is reacted with 2-(2-mercaptoethylamino)-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone and sodium ethoxide in ethanol to give 2-[2-(2-guanidino-4-thiazolylmethylthio)ethylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone.

Sources & evidence

ORD record
ord-0122eb864588414d9f323ca4b1491c4e
Source dataset
uspto-grants-1985_06
Patent number
US04521418

Reaction notes

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