Benzoic anhydride → HCID 178424601, compound

HRID 1247904Notes

Reaction equation

HRID 1247904 reaction equation
N([C:5]1[S:6][CH:7]=[C:8]([CH2:10][S:11][CH2:12][CH2:13][NH:14][C:15]2[NH:20][C:19](=[O:21])[C:18]([CH2:22][C:23]3[CH:24]=[N:25][C:26]([CH3:29])=[CH:27][CH:28]=3)=[CH:17][N:16]=2)[N:9]=1)C(N)=N.[C:30]([O:33]C(=O)C)(=O)[CH3:31].[C:37]([O:45]C(=O)C1C=CC=CC=1)(=O)[C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1>N1C=CC=CC=1>[C:30]([N:14]=[C:15]([NH2:20])[NH:16][CH:10]([C:8]1[N:9]=[CH:5][S:6][CH:7]=1)[S:11][CH2:12][CH2:13][NH:14][C:15]1[NH:20][C:19](=[O:21])[C:18]([CH2:22][C:23]2[CH:24]=[N:25][C:26]([CH3:29])=[CH:27][CH:28]=2)=[CH:17][N:16]=1)(=[O:33])[CH3:31].[C:37]([N:14]=[C:15]([NH2:20])[NH:16][CH:10]([C:8]1[N:9]=[CH:5][S:6][CH:7]=1)[S:11][CH2:12][CH2:13][NH:14][C:15]1[NH:20][C:19](=[O:21])[C:18]([CH2:22][C:23]2[CH:24]=[N:25][C:26]([CH3:29])=[CH:27][CH:28]=2)=[CH:17][N:16]=1)(=[O:45])[C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1

Participants

6

Reactant 3

HCID 7167Benzoic anhydrideHCID 7918Acetic AnhydrideHCID 178424600HCID 178424600, compound

Product 2

HCID 178424601HCID 178424601, compoundHCID 178475107HCID 178475107, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Reaction of 2-[2-(2-guanidino-4-thiazolylmethylthio)ethylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone with acetic anhydride or benzoic anhydride in pyridine gives 2-[2-(2-acetylguanidino-4-thiazolylmethylthio)ethylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone and 2-[2-(2-benzoylguanidino-4-thiazolylmethylthio)ethylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone.

Sources & evidence

ORD record
ord-f09a73de180b41ffb14767a38ffcc853
Source dataset
uspto-grants-1985_06
Patent number
US04521418

Reaction notes

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