HRID1247904

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7167

Benzoic anhydride

C14H10O3

HCID7918

Acetic anhydride

C4H6O3

结构：Cc1ccc(Cc2cnc(NCCSCc3csc(NC(=N)N)n3)[nH]c2=O)cn1

HCID178424600

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(Cc2cnc(NCCSC(NC(N)=NC(=O)c3ccccc3)c3cscn3)[nH]c2=O)cn1

HCID178424601

未命名化合物

结构：CC(=O)N=C(N)NC(SCCNc1ncc(Cc2ccc(C)nc2)c(=O)[nH]1)c1cscn1

HCID178475107

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID1049

Pyridine

C5H5N

PROCEDURE

实验过程

Reaction of 2-[2-(2-guanidino-4-thiazolylmethylthio)ethylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone with acetic anhydride or benzoic anhydride in pyridine gives 2-[2-(2-acetylguanidino-4-thiazolylmethylthio)ethylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone and 2-[2-(2-benzoylguanidino-4-thiazolylmethylthio)ethylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f09a73de180b41ffb14767a38ffcc853
来源数据集: uspto-grants-1985_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04521418
来源说明: uspto-grants-1985_06

反应 SMILES

N([C:5]1[S:6][CH:7]=[C:8]([CH2:10][S:11][CH2:12][CH2:13][NH:14][C:15]2[NH:20][C:19](=[O:21])[C:18]([CH2:22][C:23]3[CH:24]=[N:25][C:26]([CH3:29])=[CH:27][CH:28]=3)=[CH:17][N:16]=2)[N:9]=1)C(N)=N.[C:30]([O:33]C(=O)C)(=O)[CH3:31].[C:37]([O:45]C(=O)C1C=CC=CC=1)(=O)[C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1>N1C=CC=CC=1>[C:30]([N:14]=[C:15]([NH2:20])[NH:16][CH:10]([C:8]1[N:9]=[CH:5][S:6][CH:7]=1)[S:11][CH2:12][CH2:13][NH:14][C:15]1[NH:20][C:19](=[O:21])[C:18]([CH2:22][C:23]2[CH:24]=[N:25][C:26]([CH3:29])=[CH:27][CH:28]=2)=[CH:17][N:16]=1)(=[O:33])[CH3:31].[C:37]([N:14]=[C:15]([NH2:20])[NH:16][CH:10]([C:8]1[N:9]=[CH:5][S:6][CH:7]=1)[S:11][CH2:12][CH2:13][NH:14][C:15]1[NH:20][C:19](=[O:21])[C:18]([CH2:22][C:23]2[CH:24]=[N:25][C:26]([CH3:29])=[CH:27][CH:28]=2)=[CH:17][N:16]=1)(=[O:45])[C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1