3-Acetylpyridine → 3-Diethylamino-1-(3-pyridinyl)-2-propen-1-one

HRID 1247956Notes

Reaction equation

HRID 1247956 reaction equation
[C:1]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=1)(=[O:3])[CH3:2].CO[CH:12](OC)[N:13]([CH2:16][CH3:17])[CH2:14][CH3:15]>O1CCOCC1>[CH2:14]([N:13]([CH2:16][CH3:17])[CH:12]=[CH:2][C:1]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=1)=[O:3])[CH3:15]

Participants

4

Reactant 2

HCID 95893-AcetylpyridineHCID 12747026N-(Dimethoxymethyl)-N-ethylethanamine

Product 1

HCID 544535143-Diethylamino-1-(3-pyridinyl)-2-propen-1-one

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of 0.10 mole of 3-acetylpyridine and 0.10 mole of N,N-diethylformamide dimethylacetal in 100 ml of dioxane was refluxed for 10 hours. The solvent was removed, giving 3-diethylamino-1-(3-pyridinyl)-2-propen-1-one.

Workup

  1. temperaturewas refluxed for 10 hours
  2. customThe solvent was removed

Sources & evidence

ORD record
ord-f251af5646414a149ab646cab16b7be3
Source dataset
uspto-grants-1985_06
Patent number
US04521422

Reaction notes

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