3-Acetylpyridine → 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one

HRID 1247957Notes

Reaction equation

HRID 1247957 reaction equation
[C:1]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=1)(=[O:3])[CH3:2].C(O[CH:14](OCCC)[N:15]([CH3:17])[CH3:16])CC>>[CH3:14][N:15]([CH3:17])[CH:16]=[CH:2][C:1]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=1)=[O:3]

Participants

3

Reactant 2

HCID 95893-AcetylpyridineHCID 801051,1-Dipropoxytrimethylamine

Product 1

HCID 5670331-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one

Conditions

Temperature
100 °C

Procedure

A mixture of 25 g of 3-acetylpyridine and 35 ml of N,N-dimethylformamide dipropylacetal was heated at 100° C. for 6 hours. The mixture was concentrated in vacuo and the residue crystallized, giving 3-dimethylamino-1-(3-pyridinyl)-2-propen-1-one.

Workup

  1. concentrationThe mixture was concentrated in vacuo
  2. customthe residue crystallized

Sources & evidence

ORD record
ord-87f549b9bb1f4a51b634f750a76c3a45
Source dataset
uspto-grants-1985_06
Patent number
US04521422

Reaction notes

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