3-Acetylpyridine → 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one

HRID 1247959Notes

Reaction equation

HRID 1247959 reaction equation
[C:1]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=1)(=[O:3])[CH3:2].[CH3:10][N:11]([CH:13](N(C)C)N(C)C)[CH3:12]>C1C=CC=CC=1>[CH3:10][N:11]([CH3:13])[CH:12]=[CH:2][C:1]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=1)=[O:3]

Participants

4

Reactant 2

HCID 95893-AcetylpyridineHCID 79831N,N,N',N',N'',N''-Hexamethylmethanetriamine

Product 1

HCID 5670331-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A mixture of 0.02 mole of 3-acetylpyridine and 0.022 mole of tris(dimethylamino)methane in benzene was refluxed for 5 hours, giving 3-dimethylamino-1-(3-pyridinyl)-2-propen-1-one.

Workup

  1. temperaturewas refluxed for 5 hours

Sources & evidence

ORD record
ord-35fb758ea1854662b2df09c2a68bec3b
Source dataset
uspto-grants-1985_06
Patent number
US04521422

Reaction notes

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