反应详情

温度

0 °C

To a solution of 7.5 g of 4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine and 4.6 ml of triethylamine in 40 ml of methylene chloride, 6.75 g of 1-naphthylacetyl chloride in 30 ml of methylene chloride area added dropwise at 0° C. The mixture is stirred at 0° C. for 2 hours and water is added. The organic phase is separated, washed with water many times and concentrated under reduce pressure to give 11 g of crude product. Crystallization from 95% ethanol yields 8 g of 1-(1-napthylacetyl)4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine; m.p. 137°-140° C.

1. customThe organic phase is separated
2. washwashed with water many times
3. concentrationconcentrated
4. customto give 11 g of crude product
5. customCrystallization from 95% ethanol