참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 2-(Naphthalen-1-yl)acetyl chloride | HCID 2795386 | — |
| 반응물 | 4-[3-(Trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine | HCID 11128034 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 1-(1-Napthylacetyl)4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine | HCID 13277372 | 61.3% |
반응 단계
To a solution of 7.5 g of 4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine and 4.6 ml of triethylamine in 40 ml of methylene chloride, 6.75 g of 1-naphthylacetyl chloride in 30 ml of methylene chloride area added dropwise at 0° C. The mixture is stirred at 0° C. for 2 hours and water is added. The organic phase is separated, washed with water many times and concentrated under reduce pressure to give 11 g of crude product. Crystallization from 95% ethanol yields 8 g of 1-(1-napthylacetyl)4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine; m.p. 137°-140° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04521428 |
|---|
| 출처 데이터셋 | uspto-grants-1985_06 |
|---|
| ORD ID | ord-a5c7a2c920cf482f887cd5f84b831187 |
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| 출처 메모 | uspto-grants-1985_06 |
|---|
