化工社化工社 化学情報印刷レポート · 研究参考用
Triethylamine → 1-(2-Naphthylacetyl)-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 2-(2-Naphthyl)acetyl chloride | HCID 588115 | — |
| 反応物 | 4-[3-(Trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine | HCID 11128034 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 1-(2-Naphthylacetyl)-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine | HCID 13277374 | 75.7% |
反応手順
By operating as described in Example 6(a), 7 g of 4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine are reacted with 6.15 g of 2-naphthylacetyl chloride in the presence of 4.15 g of triethylamine in methylene chloride to give 9 g of 1-(2-naphthylacetyl)-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine; m.p. 125°-130° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04521428 |
| 出典データセット | uspto-grants-1985_06 |
| ORD ID | ord-47ed5670983843d5937ff17dc215f293 |
| 出典メモ | uspto-grants-1985_06 |