反应详情

Crystalline anhydrous hydroquinone (19.5 g) was added to a 1 cm diameter jacketed glass chromatography column filled with heptane. The heptane was then drained to the level of the top of the packed hydroquinone, cold acetone poured into the jacket to chill the column contents below -10° C., and Unitene-D (20 g) added. The column contents were then eluted with heptane (about 250 ml) with continued chilling over 2 hours. This removed most of the undesirable components of the feed. The jacket was then drained of coolant and the column warmed to room temperature. Continued elution with heptane provided a solution of 1.8-cineole (1.8 g) of 92.8% purity (solvent-free basis). This represents a 50% yield of 1,8-cineole present in the feedstock mixture.

1. additionpoured into the jacket
2. temperatureto chill the column contents below -10° C., and Unitene-D (20 g)
3. additionadded
4. washThe column contents were then eluted with heptane (about 250 ml)
5. temperaturewith continued chilling over 2 hours
6. customThis removed most of the undesirable components of the feed
7. washContinued elution with heptane