HCID 67915250, compound → HCID 13100818, compound

HRID 1248051Notes

Reaction equation

HRID 1248051 reaction equation
Cl.C([O:4][C:5](=[O:17])[CH2:6][NH:7][CH:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH2:10][CH2:9]1)C>Cl>[CH:8]1([NH:7][CH2:6][C:5]([OH:17])=[O:4])[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH2:10][CH2:9]1

Participants

3

Reactant 1

HCID 67915250HCID 67915250, compound

Product 1

HCID 13100818HCID 13100818, compoundYield 89.2%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

N-(1-Indanyl)glycine ethyl ester hydrochloride (9.0 g) is dissolved in 100 ml of 5N hydrochloric acid, and the mixture is refluxed for 4 hours. The reaction mixture is concentrated to dryness under reduced pressure, 10 ml of water is added to the residue, and the mixture is neutralized with aqueous ammonia. The resulting crystalline precipitates are collected by filtration, washed with water, and dried, to give 6.0 g N-(1-indanyl)glycine as colorless needles. Melting point: 184°-186° C.

Workup

  1. temperaturethe mixture is refluxed for 4 hours
  2. concentrationThe reaction mixture is concentrated to dryness under reduced pressure, 10 ml of water
  3. additionis added to the residue
  4. customThe resulting crystalline precipitates
  5. filtrationare collected by filtration
  6. washwashed with water
  7. customdried

Sources & evidence

ORD record
ord-989cb7eaba3d4fc2ac45d5e8f76345c4
Source dataset
uspto-grants-1985_06
Patent number
US04521607

Reaction notes

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