HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Chloride → 5-[4-(6-Chloro-2-quinoxalinyloxy)phenoxy]-2,4-hexanedione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Chloride | HCID 5234 | — |
| Reactant | Methyl acetoacetate | HCID 7757 | — |
| Reactant | Valerate | HCID 114781 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | HCID 13370018 | HCID 13370018 | — |
| Reactant | Methyl 2-acetyl-4-[4-(6-chloro-2-quinoxalinyloxy)phenoxy]-3-oxopentanoate | HCID 20278385 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 5-[4-(6-Chloro-2-quinoxalinyloxy)phenoxy]-2,4-hexanedione | HCID 20278374 | — |
Reaction Steps
In the same manner, methyl 2-acetyl-4-[4-(6-chloro-2-quinoxalinyloxy)phenoxy]-3-oxopentanoate (XIV; X' is chloro and X" is hydrogen) is prepared from 2-[4-(6-chloro-2-quinoxalinyloxy)phenoxy]propionic acid chloride and the sodium salt of methylacetoacetate. This pentanoate is then heated with sodium chloride and DMSO to yield 5-[4-(6-chloro-2-quinoxalinyloxy)phenoxy]-2,4-hexanedione (XV; X' is chloro and X" is hydrogen).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04522647 |
| Source dataset | uspto-grants-1985_06 |
| ORD ID | ord-9b72120cad0342589a705af1a8c908ea |
| Source note | uspto-grants-1985_06 |