Formamide → Hydrochloric Acid

HRID 1248128Notes

Reaction equation

HRID 1248128 reaction equation
C([NH:3][CH:4]([C:6]1([C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[C:12]([Cl:17])[CH:11]=2)[CH2:9][CH2:8][CH2:7]1)[CH3:5])=O.C(N)=O>>[ClH:16].[Cl:17][C:12]1[CH:11]=[C:10]([C:6]2([CH:4]([NH2:3])[CH3:5])[CH2:9][CH2:8][CH2:7]2)[CH:15]=[CH:14][C:13]=1[Cl:16]

Participants

4

Reactant 2

HCID 713FormamideHCID 23292610N-formyl-1-[1-(3,4-dichlorophenyl)cyclobutyl]ethylamine

Product 2

HCID 313Hydrochloric AcidHCID 130831401-[1-(3,4-Dichlorophenyl)cyclobutyl]ethylamine

Procedure

The preparation of N-formyl-1-[1-(3,4-dichlorophenyl)cyclobutyl]ethylamine (m.p. 124°-125° C.) (Example 1(a) Formula I R1 =Me; R2 =H; R3 =H; R4 =CHO; R5 =4-Cl and R6 =3-Cl) described above was repeated and the product isolated by cooling the reaction mixture and collecting the solid produced by filtration. The formamide was then hydrolysed by concentrated hydrochloric acid in industrial methylated spirit to give the hydrochloride salt of 1-[1-(3,4-dichlorophenyl)cyclobutyl]ethylamine.

Workup

  1. customthe product isolated
  2. temperatureby cooling the reaction mixture
  3. customcollecting the solid
  4. customproduced by filtration

Sources & evidence

ORD record
ord-2ceaea4b9ae94efb952e64f263b58a0b
Source dataset
uspto-grants-1985_06
Patent number
US04522828

Reaction notes

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