Hydrochloric Acid → HCID 20134489, compound

HRID 1248150Notes

Reaction equation

HRID 1248150 reaction equation
[NH2:1][C:2]1[C:15]([Cl:16])=[CH:14][C:5]([CH:6]([OH:13])[CH2:7][NH:8]C(C)(C)C)=[CH:4][C:3]=1[Cl:17].Cl.[CH3:19]O>>[ClH:16].[NH2:1][C:2]1[C:15]([Cl:16])=[CH:14][C:5]([CH:6]([O:13][CH3:19])[CH2:7][NH2:8])=[CH:4][C:3]=1[Cl:17]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 2783Clenbuterol

Product 1

HCID 20134489HCID 20134489, compound

Procedure

In 100 ml of methanol, 10 g of 4-amino-α-[(tert-butylamino)methyl]-3,5-dichlorobenzyl alcohol is stirred in an ice bath and dry HCl gas is introduced into the solution. After saturation of the solution, the mixture is stirred at room temperature for an hour and evaporated to dryness. The solid is then stirred in ethyl acetate to afford the title product, which is collected by filtration.

Workup

  1. customevaporated to dryness
  2. stirringThe solid is then stirred in ethyl acetate

Sources & evidence

ORD record
ord-06c6ce08e0744b42a8aca4e93d1abf05
Source dataset
uspto-grants-1985_06
Patent number
US04522822

Reaction notes

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