Hydrogen Bromide → HCID 20530721, compound

HRID 1248204Notes

Reaction equation

HRID 1248204 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH:18]=[CH:19][CH:20]=1)[C:5]([CH:7]1[CH2:12][CH2:11][N:10](C(OCC)=O)[CH2:9][CH2:8]1)=[O:6].[BrH:21]>O>[BrH:21].[CH3:1][C:2]1[CH:3]=[C:4]([C:5]([CH:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)=[O:6])[CH:18]=[CH:19][CH:20]=1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 12852041Ethyl 4-(3-methylbenzoyl)-1-piperidinecarboxylate

Product 1

HCID 20530721HCID 20530721, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 12 parts of ethyl 4-(3-methylbenzoyl)-1-piperidinecarboxylate and 225 parts of a hydrobromic acid solution 48% in water is stirred and refluxed for 3 hours. The reaction mixture is evaporated and the residue is crystallized from 2-propanol, yielding 7.5 parts of (3-methylphenyl) (4-piperidinyl)methanone hydrobromide.

Workup

  1. temperaturerefluxed for 3 hours
  2. customThe reaction mixture is evaporated
  3. customthe residue is crystallized from 2-propanol

Sources & evidence

ORD record
ord-686eab9ad3834c989540a878d74ade86
Source dataset
uspto-grants-1985_06
Patent number
US04522945

Reaction notes

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