Hydrochloric Acid → HCID 15087809, compound

HRID 1248208Notes

Reaction equation

HRID 1248208 reaction equation
[NH2:1][C:2]1[C:10]([Cl:11])=[CH:9][C:8]([Cl:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].Cl.[CH2:14](O)[CH3:15]>>[NH2:1][C:2]1[C:10]([Cl:11])=[CH:9][C:8]([Cl:12])=[CH:7][C:3]=1[C:4]([O:6][CH2:14][CH3:15])=[O:5]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 760363,5-Dichloroanthranilic acid

Product 1

HCID 15087809HCID 15087809, compound

Procedure

A mixture of 50 parts of 2-amino-3,5-dichlorobenzoic acid and 240 parts of ethanol is saturated with gaseous hydrogen chloride. The whole is stirred and refluxed for 10 hours. The reaction mixture is allowed to cool and the solvent is evaporated. To the solid residue are added water and sodium hydroxide. The precipitated product is filtered off and dried, yielding 25 parts of ethyl 2-amino-3,5-dichlorobenzoate.

Workup

  1. temperaturerefluxed for 10 hours
  2. temperatureto cool
  3. customthe solvent is evaporated
  4. additionTo the solid residue are added water and sodium hydroxide
  5. filtrationThe precipitated product is filtered off
  6. customdried

Sources & evidence

ORD record
ord-28435a5bc8544087b44bd1bdd1e700f9
Source dataset
uspto-grants-1985_06
Patent number
US04522945

Reaction notes

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