Ethyl chloroformate → HCID 20278951, compound

HRID 1248236Notes

Reaction equation

HRID 1248236 reaction equation
C1(C[N:8]2[CH2:13][CH2:12][CH:11]([C:14]([C:16]3[S:17][CH:18]=[CH:19][CH:20]=3)=[O:15])[CH2:10][CH2:9]2)C=CC=CC=1.[C:21](Cl)(=[O:25])[O:22][CH2:23][CH3:24]>C1C=CC=CC=1>[S:17]1[CH:18]=[CH:19][CH:20]=[C:16]1[C:14]([CH:11]1[CH2:10][CH2:9][N:8]([C:21]([O:22][CH2:23][CH3:24])=[O:25])[CH2:13][CH2:12]1)=[O:15]

Participants

4

Reactant 2

HCID 10928Ethyl chloroformateHCID 13035939HCID 13035939, compound

Product 1

HCID 20278951HCID 20278951, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

To a stirred mixture of 15 parts of [1-(phenylmethyl)-4-piperidinyl](2-thienyl)methanone in 120 parts of benzene are added dropwise 8 parts of ethyl carbonochloridate. Upon completion, the whole is heated to reflux and stirred for 6 hours at reflux temperature. The reaction mixture is cooled, filtered and evaporated, yielding 13 parts of ethyl 4-(2-thienylcarbonyl)-1-piperidinecarboxylate as a residue.

Workup

  1. temperatureUpon completion, the whole is heated
  2. temperatureto reflux
  3. temperatureat reflux temperature
  4. temperatureThe reaction mixture is cooled
  5. filtrationfiltered
  6. customevaporated

Sources & evidence

ORD record
ord-88ea8a34173d418d98c12b38c819a2a4
Source dataset
uspto-grants-1985_06
Patent number
US04522945

Reaction notes

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