Hydrogen Bromide → (4-Piperidinyl)(2-thienyl)methanone hydrobromide

HRID 1248237Notes

Reaction equation

HRID 1248237 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([CH:8]1[CH2:13][CH2:12][N:11](C(OCC)=O)[CH2:10][CH2:9]1)=[O:7].[BrH:19]>O>[BrH:19].[NH:11]1[CH2:12][CH2:13][CH:8]([C:6]([C:2]2[S:1][CH:5]=[CH:4][CH:3]=2)=[O:7])[CH2:9][CH2:10]1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 20278951HCID 20278951, compound

Product 1

HCID 20278974(4-Piperidinyl)(2-thienyl)methanone hydrobromideYield 85%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 20 parts of ethyl 4-(2-thienylcarbonyl)-1-piperidine-carboxylate and 120 parts of hydrobromic acid solution 48% in water is stirred and refluxed for 2 hours. The reaction mixture is cooled and the precipitated product is filtered off. It is washed with 2-propanol and dried, yielding 17 parts (85%) of (4-piperidinyl)(2-thienyl)methanone hydrobromide.

Workup

  1. temperaturerefluxed for 2 hours
  2. temperatureThe reaction mixture is cooled
  3. filtrationthe precipitated product is filtered off
  4. washIt is washed with 2-propanol
  5. customdried

Sources & evidence

ORD record
ord-b06236ed105644d48c846a5f566dbdd9
Source dataset
uspto-grants-1985_06
Patent number
US04522945

Reaction notes

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