Diethyl Ether → HCID 70477224, compound

HRID 1248260Notes

Reaction equation

HRID 1248260 reaction equation
[CH2:1]([N:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[Cl:13][CH2:14][CH2:15][C:16](=[O:20])[CH2:17][CH2:18][CH3:19].CC[O:23]CC>>[ClH:13].[C:1]([N:7]1[CH2:8][CH2:9][N:10]([CH2:14][CH2:15][C:16](=[O:20])[CH2:17][CH2:18][CH3:19])[CH2:11][CH2:12]1)(=[O:23])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]

Participants

4

Reactant 3

HCID 3283Diethyl EtherHCID 27365131-HexylpiperazineHCID 134585881-Chlorohexan-3-one

Product 1

HCID 70477224HCID 70477224, compound

Conditions

Temperature
120 °C

Procedure

A mixture of 1.8 g (0.01 mole) of n-hexyl piperazine and 1.9 g (0.014 mole) of 1-chloro-3-hexanone was heated to 120° C. for 5 minutes. The reaction product was slurried with ether, filtered and crystallized from acetonitrile to yield 4.2 g of product having a melting point of 162°-164° C.

Workup

  1. filtrationfiltered
  2. customcrystallized from acetonitrile

Sources & evidence

ORD record
ord-a8738ba4fd494fac813d1a55f6e31862
Source dataset
uspto-grants-1985_06
Patent number
US04523014

Reaction notes

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