Methyl 2-bromopropionate → HCID 20279319, compound

HRID 1248283Notes

Reaction equation

HRID 1248283 reaction equation
[CH3:1][C:2]1[C:14]([N+:15]([O-])=O)=[CH:13][CH:12]=[CH:11][C:3]=1[O:4][CH:5]([CH3:10])[C:6]([O:8][CH3:9])=[O:7].BrC(C)C(OC)=O>C(O)C.[Ni]>[CH3:1][C:2]1[C:14]([NH2:15])=[CH:13][CH:12]=[CH:11][C:3]=1[O:4][CH:5]([CH3:10])[C:6]([O:8][CH3:9])=[O:7]

Participants

5

Reactant 2

HCID 95576Methyl 2-bromopropionateHCID 20279312HCID 20279312, compound

Product 1

HCID 20279319HCID 20279319, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

Methyl 2-(2-methyl-3-nitrophenoxy)propanoate (8.2 g, 40 mmole), prepared by the method of Example 1 using methyl 2-bromopropanoate, was hydrogenated in 250 ml of ethanol using 1.0 g of Raney nickel. After reduction was complete, insolubles were removed by filtration and the filtrate concentrated in vacuo. The resultant solid (7.7 g) was used in further reactions without further characterization.

Workup

  1. custominsolubles were removed by filtration
  2. concentrationthe filtrate concentrated in vacuo

Sources & evidence

ORD record
ord-8dbec77de3cc40f2bb8eacb751846a0a
Source dataset
uspto-grants-1985_06
Patent number
US04523020

Reaction notes

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