Acetic Acid → HCID 20279418, compound

Participants

Reaction Steps

10.65 g of 4-(2,6-dichlorobenzoyl)-5-hydroxybenzocyclobutene-1-carbonitrile are suspended in a mixture of 100 ml of concentrated hydrochloric acid and 100 ml of acetic acid and stirring is carried out for 4 hours at 100°. The whole is left to cool to room temperature, filtered with suction, washed thoroughly with water, left to dry in the air and recrystallised from trichloromethane/hexane with the addition of a small amount of methanol. 4-(2,6-dichlorobenzoyl)-5-hydroxybenzocyclobutene-1-carboxylic acid is obtained having a melting point of 202°-203°.

Provenance & Evidence