Acetic Acid → HCID 20279418, compound

HRID 1248352Notes

Reaction equation

HRID 1248352 reaction equation
[Cl:1][C:2]1[CH:20]=[CH:19][CH:18]=[C:17]([Cl:21])[C:3]=1[C:4]([C:6]1[C:15]([OH:16])=[CH:14][C:9]2C(C#N)=[CH:11][C:8]=2[CH:7]=1)=[O:5].[C:22]([OH:25])(=[O:24])[CH3:23]>Cl>[Cl:1][C:2]1[CH:20]=[CH:19][CH:18]=[C:17]([Cl:21])[C:3]=1[C:4]([C:6]1[C:15]([OH:16])=[CH:14][C:9]2[C:23]([C:22]([OH:25])=[O:24])=[CH:11][C:8]=2[CH:7]=1)=[O:5]

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 20279442HCID 20279442, compound

Product 1

HCID 20279418HCID 20279418, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

10.65 g of 4-(2,6-dichlorobenzoyl)-5-hydroxybenzocyclobutene-1-carbonitrile are suspended in a mixture of 100 ml of concentrated hydrochloric acid and 100 ml of acetic acid and stirring is carried out for 4 hours at 100°. The whole is left to cool to room temperature, filtered with suction, washed thoroughly with water, left to dry in the air and recrystallised from trichloromethane/hexane with the addition of a small amount of methanol. 4-(2,6-dichlorobenzoyl)-5-hydroxybenzocyclobutene-1-carboxylic acid is obtained having a melting point of 202°-203°.

Workup

  1. waitThe whole is left
  2. filtrationfiltered with suction
  3. washwashed thoroughly with water
  4. waitleft
  5. customto dry in the air
  6. customrecrystallised from trichloromethane/hexane with the addition of a small amount of methanol

Sources & evidence

ORD record
ord-aae9551044b84e6d83c737085fcc877d
Source dataset
uspto-grants-1985_06
Patent number
US04523030

Reaction notes

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