反应详情

4-Methyl-3-thiophenesulfonamide (22 g), 125 ml of methyl ethyl ketone, 16.6 g of potassium carbonate and 14.3 g of butyl isocyanate was stirred at reflux for six hours, allowed to stand overnight and then evaporated to a syrup. Water (150 ml) was added to the residue and the mixture was filtered to remove a small amount of solid. The filtrate was acidified, cooled and the resulting intermediate was filtered off. It melted at 126°-131° C.

1. temperatureat reflux for six hours
2. customevaporated to a syrup
3. additionWater (150 ml) was added to the residue
4. filtrationthe mixture was filtered
5. customto remove a small amount of solid
6. temperaturecooled
7. filtrationthe resulting intermediate was filtered off