3-Pyridylmethyl-2-methylthio-4-pyrimidone → HCID 20277881, compound

HRID 1248405Notes

Reaction equation

HRID 1248405 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:7]=[C:8]([CH2:12][N:13]([CH3:15])[CH3:14])[CH:9]=[CH:10][CH:11]=1.CS[C:18]1[NH:23][C:22](=[O:24])[C:21]([CH2:25][C:26]2[CH:27]=[N:28][CH:29]=[CH:30][CH:31]=2)=[CH:20][N:19]=1>>[CH3:15][N:13]([CH2:12][C:8]1[CH:7]=[C:6]([CH:11]=[CH:10][CH:9]=1)[O:5][CH2:4][CH2:3][CH2:2][NH:1][C:18]1[NH:23][C:22](=[O:24])[C:21]([CH2:25][C:26]2[CH:27]=[N:28][CH:29]=[CH:30][CH:31]=2)=[CH:20][N:19]=1)[CH3:14]

Participants

3

Reactant 2

HCID 127838233-Pyridylmethyl-2-methylthio-4-pyrimidoneHCID 129139503-(3-Aminopropoxy)-N,N-dimethylbenzenemethanamine

Product 1

HCID 20277881HCID 20277881, compoundYield 56.9%

Procedure

3-(3-Aminopropoxy)-N,N-dimethylbenzenemethanamine (0.98 g) and 2-(methylthio)-5-[(3-pyridinyl)methyl]-4(3H)-pyrimidinone (1 g) were heated at 140° for 16 h. The residue, after column chromatography (silica/methanol -0.88 ammonia, 79:1) gave the title compound as a yellow gum (0.96 g).

Sources & evidence

ORD record
ord-8fe36be25c9640e59faa490077bc2f28
Source dataset
uspto-grants-1985_06
Patent number
US04524071

Reaction notes

Loading…