Dimethyl Sulfate → HCID 20277870, compound

HRID 1248407Notes

Reaction equation

HRID 1248407 reaction equation
S(OC)(O[CH3:5])(=O)=O.[SH:8][C:9]1[NH:14][C:13](=[O:15])[C:12]([CH2:16][CH2:17][O:18][C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([CH2:25][O:26][CH3:27])[CH:20]=2)=[CH:11][N:10]=1>O.[OH-].[K+]>[CH3:27][O:26][CH2:25][C:21]1[CH:20]=[C:19]([CH:24]=[CH:23][CH:22]=1)[O:18][CH2:17][CH2:16][C:12]1[C:13](=[O:15])[NH:14][C:9]([S:8][CH3:5])=[N:10][CH:11]=1

Participants

5

Reactant 2

HCID 6497Dimethyl SulfateHCID 178494501HCID 178494501, compound

Product 1

HCID 20277870HCID 20277870, compoundYield 86.2%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 14797Potassium HydroxideSolvent

Procedure

Dimethyl sulphate (0.363 g) was added to a stirred solution of 2-mercapto-5-[2-[3-(methoxymethyl)phenoxy]ethyl]-4(3H)-pyrimidinone (0.85 g) in water (20 ml) and potassium hydroxide (0.163 g). After 1 h., the suspension was filtered to give the title compound (0.76 g) m.p. 129°-131°.

Workup

  1. filtrationthe suspension was filtered

Sources & evidence

ORD record
ord-a66cca254b614c92a5c2582255119bc7
Source dataset
uspto-grants-1985_06
Patent number
US04524071

Reaction notes

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