Methane → 6-Ethyl-5-propanoylpyridin-2(1H)-one

HRID 1248461Notes

Reaction equation

HRID 1248461 reaction equation
[CH2:1]([C:3]1[NH:4][C:5](=[O:16])[C:6](=[CH:10][C:11]=1[C:12](=[O:15])[CH2:13][CH3:14])C(O)=O)[CH3:2].C>C(O)C>[CH2:1]([C:3]1[NH:4][C:5](=[O:16])[CH:6]=[CH:10][C:11]=1[C:12](=[O:15])[CH2:13][CH3:14])[CH3:2]

Participants

4

Reactant 2

HCID 297MethaneHCID 132365116-Ethyl-2-oxo-5-propanoyl-1,2-dihydropyridine-3-carboxylic acid

Product 1

HCID 132365086-Ethyl-5-propanoylpyridin-2(1H)-one

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

C-2. 6-Ethyl-5-(n-propanoyl)-2(1H)-pyridinone--A 15 g portion of 6-ethyl-1,2-dihydro-2-oxo-5-(n-propanoyl)nicotinic acid was heated in an oil bath at 235°-240° C. for 5 hours, cooled and the reaction mixture dissolved in hot ethanol, treated with decolorizing charcoal and filtered. The filtrate was evaporated in dryness and the residue recrystallized from isopropyl alcohol to yield 8.2 g of 6-ethyl-5-(n-propanoyl)-2(1H)-pyridinone, m.p. 138°-140° C.

Workup

  1. temperaturecooled
  2. filtrationfiltered
  3. customThe filtrate was evaporated in dryness
  4. customthe residue recrystallized from isopropyl alcohol

Sources & evidence

ORD record
ord-39d6486eb20447b08dbe449b738d3e48
Source dataset
uspto-grants-1985_06
Patent number
US04524149

Reaction notes

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