Glycine → N-Butan-2-ylglycine

HRID 1248551Notes

Reaction equation

HRID 1248551 reaction equation
[NH2:1][CH2:2][C:3]([OH:5])=[O:4].CO.[CH3:8][C:9]([CH2:11][CH3:12])=O>[Pd].O>[CH:9]([NH:1][CH2:2][C:3]([OH:5])=[O:4])([CH2:11][CH3:12])[CH3:8]

Participants

6

Reactant 3

HCID 750GlycineHCID 887MethanolHCID 6569Methyl Ethyl Ketone

Product 1

HCID 42811N-Butan-2-ylglycine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 962WaterSolvent

Procedure

338 g of glycine (4.5 mols), 1.5 liters of methanol, 15 g of 10% Pd on C, wet with water, and 500 g of methylethylketone (6.93 mols) are charged into the autoclave.

Sources & evidence

ORD record
ord-0e503d9cabf14a2ca3a5523662e552cc
Source dataset
uspto-grants-1985_06
Patent number
US04525294

Reaction notes

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