Formaldehyde → HCID 20487215, compound

HRID 1248552Notes

Reaction equation

HRID 1248552 reaction equation
[NH2:1][CH2:2][C:3]([OH:5])=[O:4].[CH3:6]O.C=O.[H][H].[CH3:12][C:13]([CH2:15][CH3:16])=O>[Pd]>[CH3:6][N:1]([CH:13]([CH2:15][CH3:16])[CH3:12])[CH2:2][C:3]([OH:5])=[O:4]

Participants

7

Reactant 5

HCID 712FormaldehydeHCID 750GlycineHCID 887MethanolHCID 6569Methyl Ethyl KetoneHCID 178418361HCID 178418361, compound

Product 1

HCID 20487215HCID 20487215, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst2×

Procedure

Into a one-gallon autoclave 338 g (4.5 mole) glycine, 1.2 liters methanol, 10 g 10% Pd/C and 500 g methylethylketone were combined. The reaction mixture was pressurized to 77.3 kg/cm2 and heated between 105°-115° C. Pressure was maintained between 63.3 and 77.3 kg/cm2 and after about two hours 63.3 kg/cm2 hydrogen was consumed. The autoclave was cooled and 180 g (6 moles) paraformaldehyde and 5 g 10% Pd/C added and repressurized with about 77.3 kg/cm2 hydrogen. The vessel was heated and 75.2 kg/cm2 of hydrogen was consumed within 1.5 hours and a maximum temperature of 123° C.

Workup

  1. temperatureheated between 105°-115° C
  2. temperaturePressure was maintained between 63.3 and 77.3 kg/cm2
  3. customafter about two hours 63.3 kg/cm2 hydrogen was consumed
  4. temperatureThe autoclave was cooled
  5. temperatureThe vessel was heated
  6. custom75.2 kg/cm2 of hydrogen was consumed within 1.5 hours
  7. customa maximum temperature of 123° C.

Sources & evidence

ORD record
ord-2771c598ee834ecdb17d5e20e1385863
Source dataset
uspto-grants-1985_06
Patent number
US04525294

Reaction notes

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