Formaldehyde → HCID 20487215, compound

Participants

Reaction Steps

Into a one-gallon autoclave 338 g (4.5 mole) glycine, 1.2 liters methanol, 10 g 10% Pd/C and 500 g methylethylketone were combined. The reaction mixture was pressurized to 77.3 kg/cm2 and heated between 105°-115° C. Pressure was maintained between 63.3 and 77.3 kg/cm2 and after about two hours 63.3 kg/cm2 hydrogen was consumed. The autoclave was cooled and 180 g (6 moles) paraformaldehyde and 5 g 10% Pd/C added and repressurized with about 77.3 kg/cm2 hydrogen. The vessel was heated and 75.2 kg/cm2 of hydrogen was consumed within 1.5 hours and a maximum temperature of 123° C.

Provenance & Evidence