Acetic Acid → HCID 20277286, compound

HRID 1248696Notes

Reaction equation

HRID 1248696 reaction equation
C[C:2]1[NH:3][C:4]([CH2:27][CH:28]=O)=[C:5]([C:22]([O:24][CH2:25][CH3:26])=[O:23])[CH:6]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[N+:19]([O-:21])=[O:20])[C:7]=1C(OCC)=O.Cl.[NH2:31]O.[C:33]([O-:36])(=[O:35])[CH3:34].[Na+].[C:38](O)(=O)[CH3:39]>C(OC(=O)C)(=O)C>[CH3:7][C:2]1[NH:3][C:4]([CH2:27][C:28]#[N:31])=[C:5]([C:22]([O:24][CH2:25][CH3:26])=[O:23])[CH:6]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[N+:19]([O-:21])=[O:20])[C:34]=1[C:33]([O:36][CH2:38][CH3:39])=[O:35]

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 20277346HCID 20277346, compound

Product 1

HCID 20277286HCID 20277286, compound

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Procedure

Starting from a mixture of diethyl 2-methyl-4-(2-nitrophenyl)-6-formylmethyl-1,4-dihydropyridine-3,5-dicarboxylate, hydroxylamine hydrochloride and sodium acetate in acetic acid and acetic anhydride, was obtained an oil of diethyl 2-methyl-4-(2-nitrophenyl)-6-cyanomethyl-1,4-dihydropyridine-3,5-dicarboxylate, by applying an essentially similar manner to that of Example 4-(2).

Sources & evidence

ORD record
ord-8be7f180ab7b4df39b2afef751332e41
Source dataset
uspto-grants-1985_06
Patent number
US04525478

Reaction notes

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