Leucyl-glycine-pentachlorophenyl ester.hydrochloride → 4-Methylmorpholine

Participants

Reaction Steps

In 1.5 ml of DMSO was dissolved 1.0 g of the leucyl-glycine-pentachlorophenyl ester.hydrochloride obtained in above (1), and 0.427 g of N-methylmorpholine was added. The resulting mixture was immediately placed in a thermostat at 40° C. After 2 hours, 5 hours or 12 hours, 0.30 g, 0.60 g or 0.60 g, respectively, of phosphorus pentoxide was added to the polymerization system (Run Nos. 1 to 3). When the reaction was carried out at 40° C. for 6 days in total from the addition of the tertiary amine, the whole reaction mixture solidified to become gelatinous.

Provenance & Evidence