Leucyl-glycine-pentachlorophenyl ester.hydrochloride → 4-Methylmorpholine

HRID 1248746Notes

Reaction equation

HRID 1248746 reaction equation
Cl.[Cl:2][C:3]1[C:8]([O:9][C:10](=[O:21])[CH2:11][NH:12][C:13](=[O:20])[C@H:14]([CH2:16][CH:17]([CH3:19])[CH3:18])[NH2:15])=[C:7]([Cl:22])[C:6]([Cl:23])=[C:5]([Cl:24])[C:4]=1[Cl:25]>CS(C)=O>[ClH:2].[Cl:2][C:3]1[C:8]([O:9][C:10](=[O:21])[CH2:11][NH:12][C:13](=[O:20])[C@H:14]([CH2:16][CH:17]([CH3:18])[CH3:19])[NH2:15])=[C:7]([Cl:22])[C:6]([Cl:23])=[C:5]([Cl:24])[C:4]=1[Cl:25].[CH3:13][N:12]1[CH2:11][CH2:10][O:9][CH2:8][CH2:3]1

Participants

4

Reactant 1

HCID 18598480Leucyl-glycine-pentachlorophenyl ester.hydrochloride

Product 2

HCID 79724-MethylmorpholineYield 399.4%HCID 18598480Leucyl-glycine-pentachlorophenyl ester.hydrochloride

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

In 1.5 ml of DMSO was dissolved 1.0 g of the leucyl-glycine-pentachlorophenyl ester.hydrochloride obtained in above (1), and 0.427 g of N-methylmorpholine was added. The resulting mixture was immediately placed in a thermostat at 40° C. After 2 hours, 5 hours or 12 hours, 0.30 g, 0.60 g or 0.60 g, respectively, of phosphorus pentoxide was added to the polymerization system (Run Nos. 1 to 3). When the reaction was carried out at 40° C. for 6 days in total from the addition of the tertiary amine, the whole reaction mixture solidified to become gelatinous.

Sources & evidence

ORD record
ord-221ec669038749019cd9f8b2c9a5300f
Source dataset
uspto-grants-1985_06
Patent number
US04525576

Reaction notes

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